Clomid: Helping women with infertility increase their chances of pregnancy

Clomid is an oral medication that can be used to stimulate ovulation. It works by blocking estrogen receptors at the hypothalamus.
Clomid can be helpful for those trying to get pregnant who have any of the following problems:

  • Irregular ovulation
  • Unexplained infertility
  • Male factor fertility problems

CLOMID (clomiphene citrate tablets USP) is an orally administered, nonsteroidal, ovulatory stimulant designated chemically as 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy] triethylamine citrate (1:1). It has the molecular formula of C26H28ClNO • C6H8O7 and a molecular weight of 598.09.
Clomiphene citrate is a white to pale yellow, essentially odorless, crystalline powder. It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform; and insoluble in ether.CLOMID is a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer.

CLOMID is indicated for the treatment of ovulatory dysfunction in women desiring pregnancy. Impediments to achieving pregnancy must be excluded or adequately treated before beginning CLOMID therapy. Those patients most likely to achieve success with clomiphene therapy include patients with polycystic ovary syndrome (see WARNINGS: Ovarian Hyperstimulation Syndrome), amenorrhea-galactorrhea syndrome, psychogenic amenorrhea, post-oral-contraceptive amenorrhea, and certain cases of secondary amenorrhea of undetermined etiology.


Properly timed coitus in relationship to ovulation is important. A basal body temperature graph or other appropriate tests may help the patient and her physician determine if ovulation occurred. Once ovulation has been established, each course of CLOMID should be started on or about the 5th day of the cycle. Long-term cyclic theraCLOMID is indicated only in patients with demonstrated ovulatory dysfunction who meet the conditions described below:

CLOMID is indicated only in patients with demonstrated ovulatory dysfunction who meet the conditions described below:
1.Patients who are not pregnant.
2.Patients without ovarian cysts. CLOMID should not be used in patients with ovarian enlargement except those with polycystic ovary syndrome. Pelvic examination is necessary prior to the first and each subsequent course of CLOMID treatment.
3.Patients without abnormal vaginal bleeding. If abnormal vaginal bleeding is present, the patient should be carefully evaluated to ensure that neoplastic lesions are not present.
4.Patients with normal liver function.

In addition, patients selected for CLOMID therapy should be evaluated in regard to the following:

1.Estrogen Levels. Patients should have adequate levels of endogenous estrogen (as estimated from vaginal smears, endometrial biopsy, assay of urinary estrogen, or from bleeding in response to progesterone). Reduced estrogen levels, while less favorable, do not preclude successful therapy.
2.Priary Pituitary or Ovarian Failure. CLOMID therapy cannot be expected to substitute for specific treatment of other causes of ovulatory failure.
Endometriosis and Endometrial Carcinoma. The incidence of endometriosis and endometrial carcinoma increases with age as does the incidence of ovulatory disorders. Endometrial biopsy should always be performed prior to CLOMID therapy in this population.
3.Other Impediments to Pregnancy. Impediments to pregnancy can include thyroid disorders, adrenal disorders, hyperprolactinemia, and male factor infertility.
4.Uterine Fibroids. Caution should be exercised when using CLOMID in patients with uterine fibroids due to the potential for further enlargement of the fibroids.

There are no adequate or well-controlled studies that demonstrate the effectiveness of CLOMID in the treatment of male infertility. In addition, testicular tumors and gynecomastia have been reported in males using clomiphene. The cause and effect relationship between reports of testicular tumors and the administration of CLOMID is not known.Although the medical literature suggests various methods, there is no universally accepted standard regimen for combined therapy (ie, CLOMID in conjunction with other ovulation-inducing drugs). Similarly, there is no standard CLOMID regimen for ovulation induction in in vitro fertilization programs to produce ova for fertilization and reintroduction. Therefore, CLOMID is not recommended for these uses.

2 thoughts on “Clomid: Helping women with infertility increase their chances of pregnancy

  1. I was started on clomid 50mg due to having irregular periods causing difficulty concieving. I had been using ovulation tests prior to starting clomid and usually i was ovulating.. but not always. Also the length of my cycle would be 38days one month then 27 the next. So I took one round of clomid, I ovulated one week after the last dose of clomid and got pregnant that month! The only side effect I had were some headaches, but they were tolerable with tylenol and it was worth it in the long run.My husband and I were having trouble conceiving and when we went to the doctor I was diagnosed with PCOS. He put me on clomid and on the first dose I was pregnant and with twins!!! My doctor had told us it could take up to 6 months. He thinks the reason we got pregnant so fast is because of our age we were both 22. Now I am happy to say we have 2 beautiful and happy children (a boy and a girl) and t are about to turn 1month old!!! I hope all of you get what you are looking for and never lose hope !!! I wish you all the best of luck and I would recommend clomid to anyone who is having issues conceiving! God bless

  2. For me, Clomid did several things. It made me crazy honestly. I’ve never reacted that bad to a drug. Forget getting pregnant, I was driving my husband crazy. It did make me ovulate, but after 3 months on the drug we did not get pregnant, so we quit the drug. There is something to be said for medication that forces your body to do something that, for some reason, it’s not doing. Probably a good idea to find out why your body isn’t doing what it should be doing in the first place. I hear that there are a lot of miscarriages with Clomid babies, perhaps this is why.

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