Clomid is a medication that helps women address their fertility problems by stimulating the ovaries through the hypothalamus, which is the normal way through which ovulation is achieved. Clomid contains the active drug known as Clomiphene, which is a medication type known as Selective Estrogen Receptor Modulator (SERM), which reflects the way the substance interacts with the estrogen receptors situated in the hypothalamus. Estrogen receptors are located in a specialized area of the brain that has the function to connect the nervous system with the endocrine or hormone-producing system, and it is known as the hypothalamus. This region of the brain is able to release to ovulation-inducing hormones, which are known as LH and FSH.
These hormones directly stimulate the ovarian follicle to grow, mature and synthesise more estrogen, which culminates in the process known as ovulation. The ovulation is the peak event that influences fertility because it allows the sperm cells to meet the fertile ovules. The release of the hormones LH and FSH is modulated through estrogen receptors in the hypothalamus, which detect estrogen levels in the blood and monitor the intensity of the ovarian stimulation. Women who suffer from infertility or women who need in vitro fertilization may need an additional ovarian stimulation to achieve adequate ovulation and make fertilization possible.
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How does Clomid induce ovarian stimulation that may correct the abnormal hormonal balance in women affected by infertility?
Clomid (Clomiphene) works by blocking the estrogen receptors in the hypothalamus, which results in a lower number of receptors being available for interaction with the estrogen that circulates in the bloodstream. Essentially, the hypothalamus is “fooled” into detecting lower levels of estrogen than they normally are, which initiates a response from the hypothalamus to produce more LH and FSH to stimulate the ovaries more, and elevate estrogen levels back to normal. The hypothalamic hormones LH and FSH stimulate the ovarian follicles and induce their maturation, along with an increased production of female sexual hormones, such as estrogen and progesterone. When hormone levels are high enough, ovulation occurs, which makes fertilization possible. This phenomenon can also be applied during in vitro fertilization, when a condition known as ovarian hyper-stimulation is necessary to make fertilization attempts successful.
Clomid has been employed in lab and clinical settings where it was tested for safety, and it has been officially approved as solid treatment for female infertility. As with other medications, Clomid has the potential to cause side effects in infrequent cases. Adverse effects may consist of abdominal disturbances, hot flashes and temporary visual impairment in rare cases. Other side effects are also possible, but they are usually very rare and temporary. Make sure you are adequately evaluated and monitored by a physician during the treatment with Clomid.